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Structure of the human core transcription-export complex reveals a hub for multivalent interactions

The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export factor NXF1–NXT1. How TREX integrates these mar...

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Principais autores: Thomas Pühringer, Ulrich Hohmann, Laura Fin, Belén Pacheco-Fiallos, Ulla Schellhaas, Julius Brennecke, Clemens Plaschka
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2020-11-01
Serier:eLife
Fag:
mRNA packaging
mRNA export
cryo-EM
macromolecular complexes
Online adgang:https://elifesciences.org/articles/61503
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