Structure of the human core transcription-export complex reveals a hub for multivalent interactions

The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export factor NXF1–NXT1. How TREX integrates these mar...

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Autors principals:	Thomas Pühringer, Ulrich Hohmann, Laura Fin, Belén Pacheco-Fiallos, Ulla Schellhaas, Julius Brennecke, Clemens Plaschka
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2020-11-01
Col·lecció:	eLife
Matèries:	mRNA packaging mRNA export cryo-EM macromolecular complexes
Accés en línia:	https://elifesciences.org/articles/61503
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