Discovery of Ketal‐Ester Ionizable Lipid Nanoparticle with Reduced Hepatotoxicity, Enhanced Spleen Tropism for mRNA Vaccine Delivery

Abstract The safety and efficacy of the lipid nanoparticle (LNP) delivery system are crucial for the successful development of messenger RNA vaccines. We designed and synthesized a series of ketal ester lipids (KELs), featuring a biodegradable ketal moiety in the linker and ester segments in the tai...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Kai Lv, Zhenlei Yu, Jing Wang, Na Li, Apeng Wang, Tiezheng Xue, Qixin Wang, Yanqin Shi, Lu Han, Wei Qin, Jiaqi Gong, Huijuan Song, Tingting Zhang, Chunyan Chang, Hua Chen, Xijun Zhong, Jian Ding, Rui Chen, Mingliang Liu, Weiguo Zhang, Shan Cen, Yijie Dong
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley 2024-12-01
Rangatū:	Advanced Science
Ngā marau:	biodegradability ionizable lipid mRNA delivery organ tropism toxicity
Urunga tuihono:	https://doi.org/10.1002/advs.202404684
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!