Discovery of Ketal‐Ester Ionizable Lipid Nanoparticle with Reduced Hepatotoxicity, Enhanced Spleen Tropism for mRNA Vaccine Delivery

Abstract The safety and efficacy of the lipid nanoparticle (LNP) delivery system are crucial for the successful development of messenger RNA vaccines. We designed and synthesized a series of ketal ester lipids (KELs), featuring a biodegradable ketal moiety in the linker and ester segments in the tai...

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Váldodahkkit:	Kai Lv, Zhenlei Yu, Jing Wang, Na Li, Apeng Wang, Tiezheng Xue, Qixin Wang, Yanqin Shi, Lu Han, Wei Qin, Jiaqi Gong, Huijuan Song, Tingting Zhang, Chunyan Chang, Hua Chen, Xijun Zhong, Jian Ding, Rui Chen, Mingliang Liu, Weiguo Zhang, Shan Cen, Yijie Dong
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Wiley 2024-12-01
Ráidu:	Advanced Science
Fáttát:	biodegradability ionizable lipid mRNA delivery organ tropism toxicity
Liŋkkat:	https://doi.org/10.1002/advs.202404684
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