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HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner

Laterality is a basic characteristic of all life forms, from single cell organisms to complex plants and animals. For many metazoans, consistent left-right asymmetric patterning is essential for the correct anatomy of internal organs, such as the heart, gut, and brain; disruption of left-right asymm...

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Hlavní autoři: Vaibhav P. Pai, Valerie Willocq, Emily J. Pitcairn, Joan M. Lemire, Jean-François Paré, Nian-Qing Shi, Kelly A. McLaughlin, Michael Levin
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2017-10-01
Edice:Biology Open
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On-line přístup:http://bio.biologists.org/content/6/10/1445
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