Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation

Glioblastoma (GBM), an aggressive brain malignancy with a cellular hierarchy dominated by GBM stem cells (GSCs), evades antitumor immunity through mechanisms that remain incompletely understood. Like most cancers, GBMs undergo metabolic reprogramming toward glycolysis to generate lactate. Here, we s...

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Detalles Bibliográficos

Principais autores:	Shuai Wang, Tengfei Huang, Qiulian Wu, Huairui Yuan, Xujia Wu, Fanen Yuan, Tingting Duan, Suchet Taori, Yingming Zhao, Nathaniel W. Snyder, Dimitris G. Placantonakis, Jeremy N. Rich
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 2024-11-01
Series:	The Journal of Clinical Investigation
Assuntos:	Metabolism Oncology
Acceso en liña:	https://doi.org/10.1172/JCI176851
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