Spatio-temporal transcriptomics of chromothriptic SHH-medulloblastoma identifies multiple genetic clones that resist treatment and drive relapse

Abstract Paediatric medulloblastomas with chromothripsis are characterised by high genomic instability and are among the tumours with the worst prognosis. However, the molecular makeup and the determinants of the aggressiveness of chromothriptic medulloblastoma are not well understood. Here, we appl...

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Autori principali:	Ilia Kats, Milena Simovic-Lorenz, Hannah Sophia Schreiber, Pooja Sant, Jan-Philipp Mallm, Verena Körber, Albert Li, Pravin Velmurugan, Sophie Heuer, Luisa Kües, Frauke Devens, Martin Sill, Manfred Jugold, Mahmoud Moustafa, Amir Abdollahi, Frank Winkler, Andrey Korshunov, Stefan M. Pfister, Oliver Stegle, Aurélie Ernst
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2024-11-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-024-54709-w
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