Transient multifocal genomic crisis creating chromothriptic and non-chromothriptic rearrangements in prezygotic testicular germ cells

Abstract Background The co-occurrence of multiple de novo copy number variations (CNVs) is a rare phenomenon in the human genome. Recently, an “organismal CNV mutator phenotype” has been reported to result in transient genomic instability introducing multiple de novo CNVs in primary oocytes and earl...

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Principais autores:	Atsushi Hattori, Kohji Okamura, Yumiko Terada, Rika Tanaka, Yuko Katoh-Fukui, Yoichi Matsubara, Keiko Matsubara, Masayo Kagami, Reiko Horikawa, Maki Fukami
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2019-05-01
סדרה:	BMC Medical Genomics
נושאים:	Chromoanagenesis Chromosomal instability Chromothripsis Comparative genomic hybridization Complex genomic rearrangement Copy number variation
גישה מקוונת:	http://link.springer.com/article/10.1186/s12920-019-0526-3
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