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Fluorinated prodrug-engineered nano-remodeler relieves tumor hypoxia for dual-enhanced ferroptosis-immunotherapy

Summary: Ferroptosis is recognized as a form of regulated cell death characterized by iron-dependent lipid peroxidation and significant immunogenic properties. However, we observe that the hypoxic tumor microenvironment (TME) of solid tumors severely limits ferroptosis induction and antitumor immune...

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Detalhes bibliográficos
Principais autores: Jin Lei, Xinxin Sun, Jianbin Shi, Pengfei Wang, Qingyue Guan, Zhixiao Zhang, Zhonggui He, Jin Sun, Peng Huang, Jing Lin, Cong Luo, Shenwu Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-11-01
coleção:Cell Reports Medicine
Assuntos:
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2666379125005002
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