Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation
Abstract Serine racemase (SR) dysregulation associates with brain aging and Alzheimer’s disease (AD), as both a deficiency and an excess of D-serine can impact synaptic neurotransmission and the integrity of synapses. Neuronal SR decreases with aging, while glial SR is upregulated in AD. However, th...
Guardat en:
| Autors principals: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Portfolio
2026-02-01
|
| Col·lecció: | Communications Biology |
| Accés en línia: | https://doi.org/10.1038/s42003-026-09772-y |
| Etiquetes: |
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|