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The Energy Landscape of Human Serine Racemase

Human serine racemase is a pyridoxal 5′-phosphate (PLP)-dependent dimeric enzyme that catalyzes the reversible racemization of L-serine and D-serine and their dehydration to pyruvate and ammonia. As D-serine is the co-agonist of the N-methyl-D-aspartate receptors for glutamate, the most abundant exc...

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Principais autores: Samanta Raboni, Marialaura Marchetti, Serena Faggiano, Barbara Campanini, Stefano Bruno, Francesco Marchesani, Marilena Margiotta, Andrea Mozzarelli
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-01-01
Colecção:Frontiers in Molecular Biosciences
Assuntos:
pyridoxal 5′-phosphate
enzyme catalysis
allosteric regulation
conformational landscape
D-serine
N-methyl-D-aspartate receptor
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmolb.2018.00112/full
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