Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors. Loss of WRN, a DNA repair helicase, was identified as a strong vulnerability of micro...

Szczegółowa specyfikacja

Opis bibliograficzny

Główni autorzy:	Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi
Format:	Artigo
Język:	Inglês
Wydane:	Life Science Alliance LLC 2021-01-01
Seria:	Life Science Alliance
Dostęp online:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202000795
Etykiety:	Dodaj etykietę Nie ma etykietki, Dołącz pierwszą etykiete!