Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors. Loss of WRN, a DNA repair helicase, was identified as a strong vulnerability of micro...

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Principais autores:	Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Life Science Alliance LLC 2021-01-01
Series:	Life Science Alliance
Acceso en liña:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202000795
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