Structural basis for the allosteric regulation and catalytic mechanism of Staphylococcus aureus UMP kinase
Staphylococcus aureus uridine monophosphate kinase (saUMPK) functions as a hexameric enzyme that catalyzes the reversible reaction: Mg2+ ⋅ ATP + UMP ↔ Mg2+ ⋅ ADP + UDP. As a key enzyme in pyrimidine metabolism with no detectable homologs in eukaryotes, saUMPK represents an attractive antibacterial t...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Media S.A.
2026-01-01
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| Серии: | Frontiers in Microbiology |
| Предметы: | |
| Online-ссылка: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1733028/full |
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