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Structural basis for the allosteric regulation and catalytic mechanism of Staphylococcus aureus UMP kinase

Staphylococcus aureus uridine monophosphate kinase (saUMPK) functions as a hexameric enzyme that catalyzes the reversible reaction: Mg2+ ⋅ ATP + UMP ↔ Mg2+ ⋅ ADP + UDP. As a key enzyme in pyrimidine metabolism with no detectable homologs in eukaryotes, saUMPK represents an attractive antibacterial t...

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Principais autores: Yan Gao, Zhongliang Zhu, Lianyu Wang, Jiyuan Ke, Liwen Niu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-01-01
Serier:Frontiers in Microbiology
Fag:
allosteric regulation
antimicrobial target
conformational rearrangement
crystal structure
Staphylococcus aureus
UMPK
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1733028/full
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