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Ensuring enantiomeric consistency in FAPI radiopharmaceuticals: comparative analysis of (S)- and (S/R)-FAPI-46/-74 confirms pharmacological equivalence

Abstract Background Enantiomeric composition may impact binding and potentially performance of a drug product but is not routinely tested and minimum acceptance criteria are not always established. Some batches of the precursors FAPI-46 and FAPI-74 used clinically contain a mixture of (S)- and (R)-e...

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Principais autores: Magdalena Staniszewska, Ralph Hübner, Camilla Locatelli, Douglas Howard, Matilde Forni, Francis Man, Bent Wilhelm Schoultz, Syed Nuruddin, Ingrid Sofie Norberg-Schulz Hagen, Sherly Mosessian, Ken Herrmann, Valeska von Kiedrowski, Katharina Lückerath
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2026-02-01
Serier:EJNMMI Radiopharmacy and Chemistry
Fag:
FAPI-46
FAPI-74
Enantiomers
Pharmacodynamics
Pharmacokinetics
Online adgang:https://doi.org/10.1186/s41181-026-00432-4
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