cGMP-compliant high-yield automated production of [18F]AlF-FAPI-74: optimization of quality control and evaluation of molar dose impact

Abstract Background Fibroblast activation protein inhibitor (FAPI)-based positron emission tomography (PET) radiopharmaceuticals have shown promise for imaging cancer-associated fibroblasts (CAFs), a key component of the tumor microenvironment. FAPI radiopharmaceuticals offer high tumor-to-backgroun...

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Principais autores:	Ward Storms, Sofie Celen, Justine Maes, Kim Serdons, Karolien Goffin, Tjibbe De Groot, Laura Trump, Corentin Warnier, Thibault Gendron, Romaric Gérardy, Koen Van Laere, Christophe M. Deroose, Janke Kleynhans, Frederik Cleeren
格式:	Artigo
语言:	Inglês
出版:	SpringerOpen 2025-12-01
丛编:	EJNMMI Radiopharmacy and Chemistry
主题:	18F PET Al18F-FAPI-74, FAP, molar activity
在线阅读:	https://doi.org/10.1186/s41181-025-00411-1
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