Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma

We previously identified dipeptidylpeptidase 10 (DPP10) on chromosome 2 as a human asthma susceptibility gene, through positional cloning. Initial association results were confirmed in many subsequent association studies but the functional role of DPP10 in asthma remains unclear. Using the MRC Harwe...

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Autors principals:	Youming Zhang, Thanushiyan Poobalasingam, Laura L. Yates, Simone A. Walker, Martin S. Taylor, Lauren Chessum, Jackie Harrison, Loukia Tsaprouni, Ian M. Adcock, Clare M. Lloyd, William O. Cookson, Miriam F. Moffatt, Charlotte H. Dean
Format:	Artigo
Idioma:	Inglês
Publicat:	The Company of Biologists 2018-01-01
Col·lecció:	Disease Models & Mechanisms
Matèries:	DPP10 Point mutation IgE Airway resistance Asthma
Accés en línia:	http://dmm.biologists.org/content/11/1/dmm031369
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