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KCNK2-mediated regulation of MMP-2/9 by PlGF influences uterine artery function in pregnancy-induced hypertension

Abstract Background Pregnancy induced hypertension (PIH) is characterized by aberrant uterine arterial remodeling, a process tightly associated with an imbalance between placental growth factor (PlGF) and soluble fms like tyrosine kinase 1 (sFlt 1) as well as the down regulation of matrix metallopro...

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Tallennettuna:
Päätekijät: Yinzhen Chen, Mingfu Chen, Ridong Zhou, Jichang Zheng, Gongxin Yang, Meiyu Chen, Jing Tu, Hongming Lin, Hu Zhao, Chen Lin, Xiaobin Chen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2025-06-01
Sarja:BMC Pregnancy and Childbirth
Aiheet:
Pregnancy-induced hypertension (PIH)
Placental growth factor (PlGF)
KCNK2
Matrix metalloproteinases (MMP-2/9)
Uterine artery
Linkit:https://doi.org/10.1186/s12884-025-07743-5
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