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Generation of a spontaneous murine HPV + oral cancer model with site-specific oncogene insertion using CRISPR-SONIC

Abstract Human papillomavirus associated head and neck cancer (HPV + HNC) is rising globally, emphasizing the need for improved therapeutic and screening strategies. To test novel therapies and study HPV-related disease progression, it is vital to develop relevant preclinical models. However, many f...

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Principais autores: Julia Tao, Jason Murray, Hsin-Fang Tu, Darrell Fan, Ya-Chea Tsai, Ming-Hung Hu, Annie A. Wu, Deyin Xing, Chien-Fu Hung, T.-C. Wu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-06-01
coleção:Cell & Bioscience
Assuntos:
Head and neck cancer
Murine model
Human papillomavirus
HPV16
E6
E7
Acesso em linha:https://doi.org/10.1186/s13578-025-01427-5
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