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Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila

Abstract Similar to the mammalian hepatocytes, Drosophila oenocytes accumulate fat during fasting, but it is unclear how they communicate with the fat body, the major lipid source. Using a modified protocol for prolonged starvation, we show that knockdown of the sole delta 9 desaturase, Desat1 (SCD...

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Hlavní autoři: Jiayi Li, Kerui Huang, Indira Dibra, Ying Liu, Norbert Perrimon, Matias Simons
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2025-11-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-025-66571-5
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