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Heterogeneity and dynamics of DENV-specific CD8 + T cells in dengue infection

Abstract Dengue virus (DENV) is a major global health threat, with secondary heterotypic infections potentially inducing detrimental memory immune responses. Antigen-specific CD8 + T cells contribute to both protection and pathogenicity, yet how their phenotypic heterogeneity relates to disease seve...

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Principais autores: Sirawit Srikor, Waradon Sungnak, Chawinya Trakoolsoontorn, Tiraput Poonpanichakul, Natnicha Jiravejchakul, Damita Jevapatarakul, Narita Thungsatianpun, Anunya Opasawatchai, Lisa Dratva, Lorenz Kretschmer, DENFREE Thailand, Oranart Matangkasombut, Gavin Screaton, Wanwisa Dejnirattisai, Thaneeya Duangchinda, Jongeun Park, Kerstin Meyer, Juthathip Mongkolsapaya, Varodom Charoensawan, Sarah A. Teichmann, Ponpan Matangkasombut
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-06-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-026-73491-5
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