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Mouse TAPBPR shows functional similarity to human TAPBPR in shaping the MHC-I immunopeptidome

Human TAPBPR is known to function as a Major Histocompatibility Complex class I (MHC-I) peptide exchange catalyst that shapes the peptide repertoire presented to immune cells. However, investigations characterizing TAPBPR from other species are limited. Here, we characterize mouse TAPBPR, exploring...

Deskribapen osoa

Gorde:
Egile Nagusiak: Juliana Bernardi Aggio, Marcel Wacker, William Guo, Arwen F. Altenburg, Ida Hafstrand, Reem Satti, Alison McDowall, Aure Aflalo, Andreas Neerincx, Jack Welland, Alice Abreu Torres, Mikkel-Ole Skjoedt, Karsten Skjødt, Jens Bauer, Juliane S. Walz, Louise H. Boyle
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2026-04-01
Saila:Frontiers in Immunology
Gaiak:
calnexin
H2-Db
H2-Kb
immunopeptidome
MHC-I
mouse TAPBPR
Sarrera elektronikoa:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1756668/full
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