FLZ attenuates Parkinson's disease pathological damage by increasing glycoursodeoxycholic acid production via down-regulating Clostridium innocuum

Increasing evidence shows that the early lesions of Parkinson's disease (PD) originate from gut, and correction of microbiota dysbiosis is a promising therapy for PD. FLZ is a neuroprotective agent on PD, which has been validated capable of alleviating microbiota dysbiosis in PD mice. However, the d...

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Autori principali:	Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-02-01
Serie:	Acta Pharmaceutica Sinica B
Soggetti:	Parkinson's disease FLZ Glycoursodeoxycholic acid Clostridium innocuum Gut–brain axis Microbiota dysbiosis
Accesso online:	http://www.sciencedirect.com/science/article/pii/S221138352400412X
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