Genetic Perturbation of Pyruvate Dehydrogenase Kinase 1 Modulates Growth, Angiogenesis and Metabolic Pathways in Ovarian Cancer Xenografts

Pyruvate dehydrogenase kinase 1 (PDK1) blockade triggers are well characterized in vitro metabolic alterations in cancer cells, including reduced glycolysis and increased glucose oxidation. Here, by gene expression profiling and digital pathology-mediated quantification of in situ markers in tumors,...

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Principais autores:	Carolina Venturoli, Ilaria Piga, Matteo Curtarello, Martina Verza, Giovanni Esposito, Santina Venuto, Filippo Navaglia, Angela Grassi, Stefano Indraccolo
格式:	Artigo
语言:	Inglês
出版:	MDPI AG 2021-02-01
丛编:	Cells
主题:	ovarian cancer PDK1 metabolism glycolysis angiogenesis
在线阅读:	https://www.mdpi.com/2073-4409/10/2/325
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