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Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway

Precise regulation of DNA replication complex assembly requires cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK) activities to activate the replicative helicase complex and initiate DNA replication. Chemical probes have been essential in the molecular analysis of DDK-mediated regulation...

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Autori principali: Tekle Pauzaite, James Tollitt, Betul Sopaci, Louise Caprani, Olivia Iwanowytsch, Urvi Thacker, John G. Hardy, Sarah L. Allinson, Nikki A. Copeland
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2022-08-01
Serie:Biomedicines
Soggetti:
DNA replication
Dbf4-dependent kinase (DDK)
chemical probes
kinase inhibition
RB<sup>+</sup> cancer
Accesso online:https://www.mdpi.com/2227-9059/10/8/2012
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