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Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10

Abstract Background Sepsis remains a source of high mortality in hospitalized patients despite proper antibiotic approaches. Encouragingly, mesenchymal stromal cells (MSCs) and their produced extracellular vesicles (EVs) have been shown to elicit anti-inflammatory effects in multiple inflammatory co...

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Principais autores: Kyong-Su Park, Kristina Svennerholm, Ganesh V. Shelke, Elga Bandeira, Cecilia Lässer, Su Chul Jang, Rakesh Chandode, Inta Gribonika, Jan Lötvall
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-08-01
Serier:Stem Cell Research & Therapy
Fag:
Extracellular vesicles
Nanovesicles
Mesenchymal stromal cells
Outer membrane vesicles
Sepsis
Anti-inflammation
Online adgang:http://link.springer.com/article/10.1186/s13287-019-1352-4
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