Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis

Abstract Background Women have nearly twice the lifetime risk of Alzheimer’s disease (AD) as men. Hormonal and reproductive factors have been implicated; however, the role of parity, a female-specific experience, remains unknown. While epidemiological data suggest that high parity may increase the r...

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Detalhes bibliográficos

Principais autores:	Renzhi Yang, Ying He, Youkai Pan, Aoyi Geng, Fang Huang, Kai Guo, Hongsheng Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
coleção:	Immunity & Ageing
Assuntos:	Alzheimer’s disease Sex difference Hormones Multiparity Aging FOSB
Acesso em linha:	https://doi.org/10.1186/s12979-026-00565-9
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