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Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis

Abstract Background Women have nearly twice the lifetime risk of Alzheimer’s disease (AD) as men. Hormonal and reproductive factors have been implicated; however, the role of parity, a female-specific experience, remains unknown. While epidemiological data suggest that high parity may increase the r...

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Principais autores: Renzhi Yang, Ying He, Youkai Pan, Aoyi Geng, Fang Huang, Kai Guo, Hongsheng Zhang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Immunity & Ageing
Fag:
Alzheimer’s disease
Sex difference
Hormones
Multiparity
Aging
FOSB
Online adgang:https://doi.org/10.1186/s12979-026-00565-9
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