Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion o...

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Κύριοι συγγραφείς:	Taha Azad, Ragunath Singaravelu, Mathieu J.F. Crupi, Taylor Jamieson, Jaahnavi Dave, Emily E.F. Brown, Reza Rezaei, Zaid Taha, Stephen Boulton, Nikolas T. Martin, Abera Surendran, Joanna Poutou, Mina Ghahremani, Kazem Nouri, Jack T. Whelan, Jessie Duong, Sarah Tucker, Jean-Simon Diallo, John C. Bell, Carolina S. Ilkow
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	MDPI AG 2020-08-01
Σειρά:	Membranes
Θέματα:	trimerization spike protein receptor-binding domain transmembrane domain SARS-CoV-2 vaccine development
Διαθέσιμο Online:	https://www.mdpi.com/2077-0375/10/9/215
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