Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization of SARS-CoV-2 is critical to the development of effective vaccine and therapeutic strategies. In the present study, we show that the fusion o...

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主要な著者:	Taha Azad, Ragunath Singaravelu, Mathieu J.F. Crupi, Taylor Jamieson, Jaahnavi Dave, Emily E.F. Brown, Reza Rezaei, Zaid Taha, Stephen Boulton, Nikolas T. Martin, Abera Surendran, Joanna Poutou, Mina Ghahremani, Kazem Nouri, Jack T. Whelan, Jessie Duong, Sarah Tucker, Jean-Simon Diallo, John C. Bell, Carolina S. Ilkow
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2020-08-01
シリーズ:	Membranes
主題:	trimerization spike protein receptor-binding domain transmembrane domain SARS-CoV-2 vaccine development
オンライン･アクセス:	https://www.mdpi.com/2077-0375/10/9/215
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