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The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G2/M arrest and a splicing defect

The fungal priority pathogen and basidiomycete, Cryptococcus neoformans (Cn), causes lung and brain infection in predominantly immuno-compromised individuals and there is an urgent need for new treatment options. The pyrazolopyrimidine-based cyclin dependent kinase (CDK)7 inhibitor, BS-181, has anti...

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Autori principali: Pooja Sethiya, Desmarini Desmarini, Bethany Bowring, Hue Dinh, Amy K. Cain, Chirag Parsania, Catriona L. Halliday, Sharon C-A Chen, Kim Hewitt, Julianne Teresa Djordjevic
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2026-12-01
Serie:Virulence
Soggetti:
Cryptococcus neoformans
Cryptococcus gattii
CDK7 inhibitor
BS-181
cell cycle
transcription
Accesso online:https://www.tandfonline.com/doi/10.1080/21505594.2026.2629100
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