The cyclin dependent kinase (CDK)7 inhibitor BS-181 inhibits pathogenic Cryptococcus species, causing G2/M arrest and a splicing defect

The fungal priority pathogen and basidiomycete, Cryptococcus neoformans (Cn), causes lung and brain infection in predominantly immuno-compromised individuals and there is an urgent need for new treatment options. The pyrazolopyrimidine-based cyclin dependent kinase (CDK)7 inhibitor, BS-181, has anti...

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Autors principals:	Pooja Sethiya, Desmarini Desmarini, Bethany Bowring, Hue Dinh, Amy K. Cain, Chirag Parsania, Catriona L. Halliday, Sharon C-A Chen, Kim Hewitt, Julianne Teresa Djordjevic
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2026-12-01
Col·lecció:	Virulence
Matèries:	Cryptococcus neoformans Cryptococcus gattii CDK7 inhibitor BS-181 cell cycle transcription
Accés en línia:	https://www.tandfonline.com/doi/10.1080/21505594.2026.2629100
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