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Enantioenriched α-substituted glutamates/pyroglutamates via enantioselective cyclopropenimine-catalyzed Michael addition of amino ester imines

A procedure for the enantioselective synthesis of α-substituted glutamates and pyroglutamates via a cyclopropenimine-catalyzed Michael addition of amino ester imines is described. Enantioselectivities of up to 94% have been achieved, and a variety of functional groups were found to be compatible. Th...

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Príomhchruthaitheoirí: Zara M. Seibel, Jeffrey S. Bandar, Tristan H. Lambert
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Beilstein-Institut 2021-08-01
Sraith:Beilstein Journal of Organic Chemistry
Ábhair:
Rochtain ar líne:https://doi.org/10.3762/bjoc.17.134
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