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Beta-amyloid influences the content and trafficking of beta-amyloid precursor protein via Na,K-ATPase-Src kinase positive feedback loop

Beta-amyloid (Aβ) is an important factor in the development of pathology in Alzheimer’s disease. Level of beta-amyloid precursor protein (APP) is increased in neurites with age and in Alzheimer’s disease model mice. However, it is unclear whether Aβ can affect APP levels in cells. The aim of this st...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Irina Y. Petrushanko, Denis R. Lisitskii, Filipp A. Filonov, Olga G. Leonova, Vladimir A. Mitkevich, Maria A. Strelkova, Alexander A. Makarov
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2025-09-01
Sraith:Frontiers in Pharmacology
Ábhair:
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fphar.2025.1665715/full
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