Beta-amyloid influences the content and trafficking of beta-amyloid precursor protein via Na,K-ATPase-Src kinase positive feedback loop

Beta-amyloid (Aβ) is an important factor in the development of pathology in Alzheimer’s disease. Level of beta-amyloid precursor protein (APP) is increased in neurites with age and in Alzheimer’s disease model mice. However, it is unclear whether Aβ can affect APP levels in cells. The aim of this st...

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Autors principals:	Irina Y. Petrushanko, Denis R. Lisitskii, Filipp A. Filonov, Olga G. Leonova, Vladimir A. Mitkevich, Maria A. Strelkova, Alexander A. Makarov
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-09-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	beta-amyloid APP Src kinase ouabain APP trafficking Na,K-ATPase
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1665715/full
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