Discovery of oxazine-linked pyrimidine as an inhibitor of breast cancer growth and metastasis by abrogating NF-κB activation

IntroductionNuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression. We have previously reported oxazine and piperazine-linked pyrimidines as novel anti-cancer agents that can...

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मुख्य लेखकों:	Jie Yuan, Bhanuprakash C. Narasimhachar, Akshay Ravish, Li Yang, Hua Zhang, Qun Wang, Zhi Li, Jun Huang, Bei Wang, Geng Wang, Keshav Kumar Harish, Arunachalam Chinnathambi, Chandramohan Govindasamy, Mahendra Madegowda, Basappa Basappa
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2024-07-01
श्रृंखला:	Frontiers in Oncology
विषय:	breast cancer nuclear factor-κB cell viability and motility TRX-01 oxazine linked pyrimidine NF-κB activation
ऑनलाइन पहुंच:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1390992/full
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