Metabolic engineering for the production of shikimic acid in an evolved <it>Escherichia coli </it>strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system
<p>Abstract</p> <p>Background</p> <p>Shikimic acid (SA) is utilized in the synthesis of oseltamivir-phosphate, an anti-influenza drug. In this work, metabolic engineering approaches were employed to produce SA in <it>Escherichia coli </it>strains derived from an evolved strain (PB12) lacking the pho...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2010-04-01
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| coleção: | Microbial Cell Factories |
| Acesso em linha: | http://www.microbialcellfactories.com/content/9/1/21 |
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