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HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload

IntroductionGain-of-function (GOF) mutations in the cardiac pacemaker channel HCN4 have been associated with inappropriate sinus tachycardia in human patients. Chronic tachycardia is generally associated with adverse cardiac remodeling and cardiomyopathy, but whether enhanced HCN4 activity can induc...

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Principais autores: Konstantin Hennis, Julia Rilling, Linh Pham, René Rötzer, Chiara Piantoni, Yakun Wu, Nicolas Auerbach, Jürgen Groher, Daniela Kruck, Stefan Koplitz-Weißgerber, Christian Gruner, Andreas Scharr, Verena Mehlfeld, Martin Biel, Christian Wahl-Schott, Stefanie Fenske
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Pharmacology
Fag:
adaptive remodeling
gain-of-function mutation
HCN4
pacemaker channels
pressure-overload
sinoatrial node
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2026.1840832/full
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