HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload

IntroductionGain-of-function (GOF) mutations in the cardiac pacemaker channel HCN4 have been associated with inappropriate sinus tachycardia in human patients. Chronic tachycardia is generally associated with adverse cardiac remodeling and cardiomyopathy, but whether enhanced HCN4 activity can induc...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Konstantin Hennis, Julia Rilling, Linh Pham, René Rötzer, Chiara Piantoni, Yakun Wu, Nicolas Auerbach, Jürgen Groher, Daniela Kruck, Stefan Koplitz-Weißgerber, Christian Gruner, Andreas Scharr, Verena Mehlfeld, Martin Biel, Christian Wahl-Schott, Stefanie Fenske
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Frontiers Media S.A. 2026-06-01
سلاسل:	Frontiers in Pharmacology
الموضوعات:	adaptive remodeling gain-of-function mutation HCN4 pacemaker channels pressure-overload sinoatrial node
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1840832/full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!