Evaluating the impact of annealing and radiative cooling on a PEGylated peptide formulation subjected to continuous spin-freeze-drying

Abstract Annealing is commonly used in traditional lyophilization processes to crystallize solutes, improve drying efficiency and reduce cake heterogeneity, yet its integration into continuous spin-freeze-drying has not yet been reported. This study investigates the effects of incorporating annealin...

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Detalhes bibliográficos

Principais autores:	Zarah Schaal, Pieter-Jan Van Bockstal, Joris Lammens, Julian H. Lenger, Adrian P. Funke, Stefan C. Schneid, Hristo L. Svilenov, Thomas De Beer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2026-01-01
coleção:	AAPS Open
Assuntos:	Annealing Continuous freeze-drying Biopharmaceuticals Peptide formulation Lyophilization
Acesso em linha:	https://doi.org/10.1186/s41120-025-00136-0
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