Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction

HIV reverse transcriptases (RTs) convert viral genomic RNA into double-stranded DNA. During reverse transcription, polypurine tracts (PPTs) resilient to RNase H cleavage are used as primers for plus-strand DNA synthesis. Nonnucleoside RT inhibitors (NNRTIs) can interfere with the initiation of plus-...

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主要な著者:	Mar Álvarez, Enrique Sapena-Ventura, Joanna Luczkowiak, Samara Martín-Alonso, Luis Menéndez-Arias
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2021-01-01
シリーズ:	Viruses
主題:	HIV reverse transcriptase antiretroviral drug resistance DNA synthesis doravirine RNase H
オンライン･アクセス:	https://www.mdpi.com/1999-4915/13/1/131
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