Analysis and Molecular Determinants of HIV RNase H Cleavage Specificity at the PPT/U3 Junction
HIV reverse transcriptases (RTs) convert viral genomic RNA into double-stranded DNA. During reverse transcription, polypurine tracts (PPTs) resilient to RNase H cleavage are used as primers for plus-strand DNA synthesis. Nonnucleoside RT inhibitors (NNRTIs) can interfere with the initiation of plus-...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
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MDPI AG
2021-01-01
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| Edice: | Viruses |
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| On-line přístup: | https://www.mdpi.com/1999-4915/13/1/131 |
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