Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-l-lysine dendrimer as a gene delivery system

Antisense oligodeoxynucleotide (ASODN) can directly interfere a series of biological events of the target RNA derived from tumor cells through Watson-Crick base pairing, in turn, plays antitumor therapeutic roles. In the study, a novel HIF-1α ASODN-loaded nanocomposite was formulated to efficiently...

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Detalles Bibliográficos

Principais autores:	Jianmin Shen, Jing Chen, Jingbo Ma, Linlan Fan, Xiaoli Zhang, Ting Yue, Yaping Yan, Yuhang Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado:	KeAi Communications Co., Ltd. 2020-11-01
Series:	Asian Journal of Pharmaceutical Sciences
Assuntos:	Antisense oligodeoxynucleotide (ASODN) Gene delivery Dendrigraft poly-L-lysines (DGL) Lysosomal escape Tumor targeting
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S1818087619308839
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