Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
<p>Abstract</p> <p>Background</p> <p>Huntington's disease is caused by aggregation of mutant huntingtin (mHtt) protein containing more than a 36 polyQ repeat. Upregulation of macroautophagy was suggested as a neuroprotective strategy to degrade mutant huntingtin. However, macroautophagy initiation h...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2011-06-01
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| Serie: | Molecular Neurodegeneration |
| Soggetti: | |
| Accesso online: | http://www.molecularneurodegeneration.com/content/6/1/37 |
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