Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
<p>Abstract</p> <p>Background</p> <p>Huntington's disease is caused by aggregation of mutant huntingtin (mHtt) protein containing more than a 36 polyQ repeat. Upregulation of macroautophagy was suggested as a neuroprotective strategy to degrade mutant huntingtin. However, macroautophagy initiation h...
I tiakina i:
| Ngā kaituhi matua: | , , , |
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| Hōputu: | Artigo |
| Reo: | Inglês |
| I whakaputaina: |
BMC
2011-06-01
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| Rangatū: | Molecular Neurodegeneration |
| Ngā marau: | |
| Urunga tuihono: | http://www.molecularneurodegeneration.com/content/6/1/37 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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