Activity-Related Conformational Changes in d,d-Carboxypeptidases Revealed by In Vivo Periplasmic Förster Resonance Energy Transfer Assay in Escherichia coli

ABSTRACT One of the mechanisms of β-lactam antibiotic resistance requires the activity of d,d-carboxypeptidases (d,d-CPases) involved in peptidoglycan (PG) synthesis, making them putative targets for new antibiotic development. The activity of PG-synthesizing enzymes is often correlated with their a...

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Detalhes bibliográficos

Principais autores:	Nils Y. Meiresonne, René van der Ploeg, Mark A. Hink, Tanneke den Blaauwen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2017-11-01
coleção:	mBio
Assuntos:	FRET PBP5 PBP6a PBP6b antibiotics mCherry
Acesso em linha:	https://journals.asm.org/doi/10.1128/mBio.01089-17
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