Chemical Chaperones Reduce Aggregate Formation and Cell Death Caused by the Truncated Machado–Joseph Disease Gene Product with an Expanded Polyglutamine Stretch

Machado–Joseph disease/spinocerebellar ataxia-3 (MJD/SCA-3) is an inherited neurodegenerative disorder caused by expansion of the polyglutamine stretch in the MJD gene-encoded protein ataxin-3. The truncated form of mutated ataxin-3 causes aggregation and cell death in vitro and in vivo. Abnormal co...

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Bibliografske podrobnosti

Principais autores:	Hideaki Yoshida, Toshihiro Yoshizawa, Futoshi Shibasaki, Shin'ichi Shoji, Ichiro Kanazawa
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2002-07-01
Serija:	Neurobiology of Disease
Teme:	Machado–Joseph disease spinocerebellar ataxia-3 ataxin-3 polyglutamine aggregate cell death
Online dostop:	http://www.sciencedirect.com/science/article/pii/S0969996102905024
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