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Sample size recalculation in three-stage clinical trials and its evaluation

Abstract Background In clinical trials, the determination of an adequate sample size is a challenging task, mainly due to the uncertainty about the value of the effect size and nuisance parameters. One method to deal with this uncertainty is a sample size recalculation. Thereby, an interim analysis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Björn Bokelmann, Geraldine Rauch, Jan Meis, Meinhard Kieser, Carolin Herrmann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2024-09-01
Cyfres:BMC Medical Research Methodology
Pynciau:
Mynediad Ar-lein:https://doi.org/10.1186/s12874-024-02337-9
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