Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression

BackgroundNicotinamide adenine dinucleotide (NAD+) is vital for not only energy metabolism but also signaling pathways. A major source of NAD+ depletion is the activation of poly (ADP-ribose) polymerase (PARP) in response to DNA damage. We have previously demonstrated that metformin can cause both c...

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Bibliographic Details

Main Authors:	Yongxian Zhuang, Allison B. Haugrud, Meg A. Schaefer, Shanta M. Messerli, W. Keith Miskimins
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2023-07-01
Series:	Frontiers in Oncology
Subjects:	metformin nicotinamide adenine dinucleotide (NAD+) nicotinamide phosphoribosyltransferase (NAMPT) tumorigenesis breast cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1225220/full
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